To date, cancer researchers have successfully used Thermofield® technology in dogs, cats, and horses. Treatments involve a combination of heat + chemotherapy. Thermofield® hyperthermia therapy was given twice weekly and was monitored using the thermo-sensors designed within the applicator and verified using invasive temperature probes. Target skin temperatures ranged from 41-43°C (107-113°F) and were maintained for 45 minutes pretreatment.
Clinical activity of combination thermochemotherapy was assessed in a population of canines with loco-regionally advanced (≥T2) superficial solid tumors. This population included 37 dogs diagnosed with head and neck carcinomas, 42 dogs diagnosed with head and neck sarcomas, 18 dogs with carcinomas of other anatomic locations, 10 dogs with primary bone tumors, and >90 dogs with cutaneous and subcutaneous sarcomas of varying anatomic locations. Carboplatin chemotherapy was the drug of choice, selected on the basis of tumor histology and previous literature suggesting a synergistic interaction between platinum drugs and hyperthermia.
In each dog a target lesion, ranging from 2-6cm in diameter, was selected for thermal treatments and outcome determinations. The outcome data collected included: toxicity data, time to response, objective response, progression-free interval, and (where applicable) a description of palliative benefits. Overall, incidence of Grade III or higher toxicity in any category was <3%. Median time to response for was three weeks, and the overall objective response was 65%. Median progression-free interval for target lesions in dogs with head and neck cancer was 7.3 months, a time significantly longer than that reported in dogs treated with chemotherapy alone for either oral or nasal tumors (median 2 months and 5 months, respectively). Palliative benefits including pain mitigation and improvements in quality of life scores were evaluated in all dogs diagnosed with primary bone sarcomas. Using force-plate analysis, pain mitigation was documented in 70% of treated dogs, and all owners reported improvement in quality-of-life scores.